This site provides INTERCEPT product information for Health Care Professionals in the United States.

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Pathogen Reduction

Reduce the risk of transfusion transmitted infections by using blood products treated with the INTERCEPT® Blood System Pathogen Reduction System

Every day, blood transfusions save thousands of lives around the world. These transfusions, however, are not without risk.1

Blood can contain potentially harmful elements which can be transmitted to the patient, such as:

Bacteria
(Staph infections)

Viruses
(HIV)

Parasites
(Babesia)

Emerging Pathogens
(Zika*, West Nile Virus, Chikungunya, SARS- CoV-1)

Plasma used to make INTERCEPT® Fibrinogen Complex is pathogen reduced by the INTERCEPT Blood System for Plasma.2

  • Provides broad spectrum transfusion transmitted infection risk reduction, including viral, bacterial and parasitic pathogens
  • Enables INTERCEPT Fibrinogen Complex to be transfusion ready, at room temperature, for up to 5 days

INTERCEPT treated plasma has 20 years of clinical and post-market surveillance experience.

PROACTIVE APPROACH

INTERCEPT Blood System Mechanism of Action

Upon UVA illumination, amotosalen crosslinks nucleic acids to block replication and inactivates pathogens.

There is no pathogen inactivation process that has been shown to eliminate all pathogens. Certain non-enveloped viruses (e.g., Hepatitis A virus (HAV), hepatitis E virus (HEV), parvovirus B19 and poliovirus) and Bacillus cereus spores have demonstrated resistance to the INTERCEPT process.

For a full list of pathogens inactivated by INTERCEPT Blood System for Plasma see the Package Insert and/or learn more here.

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*Data for pathogen reduction of Zika by INTERCEPT Blood System for Plasma has not been submitted to FDA for review.
References:

  1. Dumont LJ, Kleinman S, Murphy JR, et al. Screening of single-donor apheresis platelets for bacterial contamination: the PASSPORT study results. Transfusion 2010;50:589-99.
  2. INTERCEPT Blood System for Plasma Package Insert.