How INTERCEPT works

The INTERCEPT Blood System for Platelets and Plasma, pathogen reduction system, uses amotosalen - a well characterized photoactive compound that specifically targets DNA and RNA - and UVA illumination to irreversibly cross-link nucleic acids. In doing so, INTERCEPT blocks replication of viruses, bacteria, and parasites, rendering them inactive.1

 

INTERCEPT mechanism of action

mechanism of action-step 1mechanism of action-step 2mechanism of action-step 3

  1. Amotosalen targets nucleic acids, and intercalates or "docks" between nucleic acid base pairs.
  2. UVA illumination activates amotosalen, causing permanent cross-links between the helical strands.
  3. Cross-linking prevents further replication and inactivates the pathogen and/or leukocyte.


INTERCEPT helps to protect against a broad spectrum of pathogens2,3

gram-positive-bacteria

Gram Negative Bacteria

  enveloped-virus-sm

Enveloped Viruses

 

Klebsiella pneumoniae †◊#
Yersinia enterocolitica †◊#
Escherichia coli †◊
Pseudomonas aeruginosa †◊
Salmonella choleraesuis †◊
Enterobacter cloacae †◊
Serratia marcescens †◊
Anaplasma phagocytophilum#

HIV-1†◊#
DHBV- (model for HBV)†◊#
BVDV- (model for HCV)†◊#
HTLV-1†#
HTLV-II†#
CMV
Pseudorabies Virus (Model for CMV)
WNV†◊#
Chikungunya†◊#
Dengue†◊
Influenza A †#
Bluetongue virus†#
Adenovirus†◊#

gram-negative-bacteria

Gram Positive Bacteria

Staphylococcus epidermidis†◊#
Staphylococcus aureus
†◊
Streptococcus pyogenes†◊
Listeria monocytogenes†◊
  Corynebacterium minutissimum†◊
Bacillus cereus
(vegetative)†◊
Lactobacillus species†◊
Bifidobacterium adolescentis
Propionibacterium acnes*
Clostridium perfringens
(vegetative)†◊
protozoa

Protozoa

Trypanosoma cruzi†◊#
Plasmodium falciparum†#
Babesia microti†#


spirochete

Spirochetes

leukocyte-sm

Leukocytes

Treponema pallidum†#
Borrelia Burgdorferi†#
 

Human T-cells†◊#


† pathogen reduced Amicus apheresis platelets in 65% PAS-3/35% Plasma
◊ pathogen reduced Trima apheresis platelets in 100% plasma
# pathogen reduced plasma

References:

  1. Wollowitz S. Semin Hematol 2001;38(4 Suppl 11):4-11.
  2. INTERCEPT Blood System for Platelets - Dual Storage Set Package Insert, March 15, 2016.
  3. INTERCEPT Blood System for Plasma Package Insert, August 17, 2015.

 

Amotosalen targets and cross-links nucleic acids in pathogens and T-cells, rendering them inactive.

*Certain non-enveloped viruses (e.g., HAV, HEV, B19 and poliovirus) and Bacillus cereus spores have demonstrated resistance to the INTERCEPT process.