How INTERCEPT WorksA Proactive Approach to Blood Safety
Targeting DNA and RNA to Prevent Pathogen Proliferation
The INTERCEPT® System uses amotosalen – a well characterized photoactive compound that specifically targets DNA and RNA – and UVA illumination to irreversibly cross-link nucleic acids. In doing so, the INTERCEPT treatment blocks replication of viruses, bacteria, and parasites, rendering them inactive.1
Mechanism of Action
- Amotosalen targets nucleic acids, and intercalates or “docks” between nucleic acid base pairs.
- UVA illumination activates amotosalen, causing permanent cross-links between the helical strands.
- Cross-linking prevents further replication and inactivates the pathogen and/or leukocyte.
INTERCEPT Reduces a Broad Spectrum of Pathogens1
|Klebsiella pneumoniae †◊|
|Escherichia coli †◊|
|Serratia marcescens †◊|
|Yersenia enterocolitica †◊|
|Staphylococcus epidermidis †◊|
|Staphylococcus aureus †◊|
|Streptococcus pyogenes †◊|
|Bacillus cereus (vegetative) †◊|
|Clostridium perfringens (vegetative)|
|Propionibacterium acnes †◊|
|Treponema pallidum (Syphilis) †|
|Borrelia burgdorferi (Lyme disease) †|
|HIV-1, cell associated †◊|
|DHBV (model virus for HBV) †◊|
|BVDV (model virus for HCV) †◊|
|West Nile virus (WNV) †◊|
|Chikungunya virus (CHIKV) †◊|
|Dengue virus (DENV) †◊|
|Cytomegalovirus (CMV) †|
|Pseudorabies virus (model for CMV) ◊|
|Influenza A virus †|
|Bluetongue virus (model non-enveloped virus) †|
|Plasmodium falciparum †|
|Babesia microti †|
|Trypanosoma cruzi †◊|
|Human T-Cells †◊|
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For a full list of pathogens, see Package Insert.
† Pathogen reduced Amicus apheresis platelets in PAS-3. ◊ Pathogen reduced Trima apheresis platelets in 100% plasma.
1. The INTERCEPT Blood System for Platelets Package Insert, Cerus Corporation; May 28, 2019.
*Certain non-enveloped viruses (e.g., HAV, HEV, B19, and poliovirus) and Bacillus cereus spores have demonstrated resistance to the INTERCEPT process.