Targeting DNA and RNA to prevent pathogen proliferation.
The INTERCEPT® System uses amotosalen - a well characterized photoactive compound that specifically targets DNA and RNA - and UVA illumination to irreversibly cross-link nucleic acids. In doing so, the INTERCEPT treatment blocks replication of viruses, bacteria, and parasites, rendering them inactive.1
- Amotosalen targets nucleic acids, and intercalates or "docks" between nucleic acid base pairs.
- UVA illumination activates amotosalen, causing permanent cross-links between the helical strands.
- Cross-linking prevents further replication and inactivates the pathogen and/or leukocyte.
(gram-negative, gram-positive, spirochetes)
|Klebsiella pneumoniae †◊|
|Escherichia coli †◊|
|Serratia marcescens †◊|
|Yersenia enterocolitica †◊|
|Staphylococcus epidermidis †◊|
|Staphylococcus aureus †◊|
|Streptococcus pyogenes †◊|
|Bacillus cereus (vegetative) †◊|
|Clostridium perfringens (vegetative)|
|Propionibacterium acnes †◊|
|Treponema pallidum (Syphilis) †|
|Borrelia burgdorferi (Lyme disease) †|
(enveloped and non-enveloped)
|HIV-1, cell associated †◊|
|DHBV (model virus for HBV) †◊|
|BVDV (model virus for HCV) †◊|
|West Nile virus (WNV) †◊|
|Chikungunya virus (CHIKV) †◊|
|Dengue virus (DENV) †◊|
|Cytomegalovirus (CMV) †|
|Pseudorabies virus (model for CMV) ◊|
|Influenza A virus †|
|Bluetongue virus (model non-enveloped virus) †|
|Plasmodium falciparum †|
|Babesia microti †|
|Trypanosoma cruzi †◊|
|Human T-Cells †◊|
For a full list of pathogens, see Package Insert.
† pathogen reduced Amicus apheresis platelets in PAS-3
◊ pathogen reduced Trima apheresis platelets in 100% plasma
- The INTERCEPT Blood System for Platelets Package Insert, Cerus Corporation; July 17, 2018.
*Certain non-enveloped viruses (e.g., HAV, HEV, B19 and poliovirus) and Bacillus cereus spores have demonstrated resistance to the INTERCEPT process.