A Proactive Approach
to Blood Safety

Cerus Final Intercept United States 3

Targeting DNA and RNA to prevent pathogen proliferation.

The INTERCEPT® System uses amotosalen - a well characterized photoactive compound that specifically targets DNA and RNA - and UVA illumination to irreversibly cross-link nucleic acids. In doing so, the INTERCEPT treatment blocks replication of viruses, bacteria, and parasites, rendering them inactive.1

 

INTERCEPT mechanism of action

mechanism of action-step 1
mechanism of action-step 2
mechanism of action-step 1

  1. Amotosalen targets nucleic acids, and intercalates or "docks" between nucleic acid base pairs.
  2. UVA illumination activates amotosalen, causing permanent cross-links between the helical strands.
  3. Cross-linking prevents further replication and inactivates the pathogen and/or leukocyte.


INTERCEPT reduces a broad spectrum of pathogens1

Jump to: Bacteria,VirusesProtozoaLeukocytes


bacteria table header
Bacteria
(gram-negative, gram-positive, spirochetes)
Klebsiella pneumoniae †◊
Escherichia coli †◊
Serratia marcescens †◊
Yersenia enterocolitica †◊
Staphylococcus epidermidis †◊
Staphylococcus aureus †◊
Streptococcus pyogenes †◊
Bacillus cereus (vegetative) †◊
Clostridium perfringens (vegetative)
Propionibacterium acnes †◊
Treponema pallidum (Syphilis) 
Borrelia burgdorferi (Lyme disease) 
 
virus table header
Virus
(enveloped and non-enveloped)
HIV-1, cell associated †◊
DHBV (model virus for HBV) †◊
BVDV (model virus for HCV) †◊
HTLV-I 
HTLV-II 
West Nile virus (WNV) †◊
Chikungunya virus (CHIKV) †◊
Dengue virus (DENV) †◊
Cytomegalovirus (CMV) 
Pseudorabies virus (model for CMV) 
Influenza A virus 
Bluetongue virus (model non-enveloped virus) 
 
Protozoan Parasite
Plasmodium falciparum 
Babesia microti 
Trypanosoma cruzi †◊
 
Leukocyte
Human T-Cells †◊

For a full list of pathogens, see Package Insert.

† pathogen reduced Amicus apheresis platelets in PAS-3 
◊ pathogen reduced Trima apheresis platelets in 100% plasma  


    1. The INTERCEPT Blood System for Platelets Package Insert, Cerus Corporation; July 17, 2018.

*Certain non-enveloped viruses (e.g., HAV, HEV, B19 and poliovirus) and Bacillus cereus spores have demonstrated resistance to the INTERCEPT process.